Personally, I don't really see the need for the 6.2 ltr. The 5.3 ltr has more than enough power for most situations, and is quite happy on regular gas. The 6.2 will run fine on regular, but the computer system will reduce the max power output to compensate for the lower octane fuel.
I have a 2016 GMC 1500 crew cab SLT 6.5 bed, with the 5.3 ltr, 6 speed and 3.42 rear. I regularly tow a cargo trailer weighing 5,000 - 7,000 lbs, and occasionally tow a friend's race car trailer, that weights around 7,500-8000 lbs. The 5.3 is more than sufficient for towing either trailer, and averages 11-12 mpg towing at 70-75 mph. Normal highway driving usually returns around 22 mpg, but on a recent trip home from Watkins Glen, I averaged 24.3 on the PA Turnpike, with the cruise set at 80! Locally I get around 16.5-17 mpg.
Previously I had a 2011 Silverado 1500 extended cab LTZ, with the 5.3, 6 speed and 3.42. The Silverado got similar mileage towing, but only averaged around 15-16 locally and never broke 20 mpg on the highway. I will say that the 2016 GMC seems to ride a little harsher than my '11 Silverado, which surprised me a little, considering the longer wheelbase of the GMC. Both trucks ride on the same Goodyear Eagle LS 20's, and neither has the Z-71 package, so I'm guessing the higher tow and cargo rating of the '16 crew cab, is the main reason for the difference in ride.
The GMC's 6 speed seemed to have a few shifting issues when delivered, especially when towing, but after about a thousand miles it seemed to "learn" my driving style, and shifts fine now. My wife has a 2017 Cadillac XT5, with the front/all wheel drive version of the 8 speed. It does seem to have a few quirks, but no where near as bad as some of the stories I've heard. The interaction between the Start/Stop system, and the 8 speed, is the biggest issue I've noticed.